Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Zhen-Zhen ZHOU, Hong-Jie ZHU, Cheng-Long YANG, Yan-Jun LIU, Nan JIANG, Yong-Sheng XIAO, Li-Yun SHI, Rui-Hua JIAO, Hui-Ming GE, Ren-Xiang TANAbstractReplacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research