Six new monacolin analogs from red yeast rice

Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Bing-Yu LIU, Fei XU, Jian BAI, Dao-Jiang YAN, Le ZHANG, Dan ZHANG, You-Cai HUAbstractSix novel monacolin analogs, monacolins V1–V6 (1–6), together with seven known ones (7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V2 (2) and V3 (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research