A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.
Source: Journal of Cell Biology - Category: Cytology Authors: Tags: Spotlight Source Type: research