Who plays the ferryman: ATG2 channels lipids into the forming autophagosome

Expansion of the autophagosomal membrane requires a mechanism to supply lipids while excluding most membrane proteins. In this issue, Valverde et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201811139) identify ATG2, a member of the autophagy-related protein family, as a lipid transfer protein and provide important novel insights on how autophagosomes grow.

Source: Journal of Cell Biology - June 2, 2019 Category: Cytology Authors: Ktistakis, N. T. Tags: Spotlight Source Type: research