IL2RB maintains immune harmony

How the IL-2 receptor β-chain specifically shapes immunity has remained enigmatic. In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20182304) and Fernandez et al. (https://doi.org/10.1084/jem.20182015) independently report the first observations of autosomal recessive mutations in IL2RB, revealing a requirement for IL2RB in immunity and peripheral immune tolerance.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Autoimmunity, Immunodeficiency, Infectious Disease and Host Defense, Human Disease Genetics Insights Source Type: research