Implementation of standardized assessment and reporting of myocardial infarction in contemporary randomized controlled trials: a systematic review

Source: European Heart Journal Area: Evidence > Medicines Management > References Myocardial infarction (MI) is a key endpoint in randomised controlled trials (RCTs), but heterogeneous definitions limit comparisons across RCTs or meta-analyses.  The 2000 European Society of Cardiology/American College of Cardiology MI redefinition and the 2007 universal MI definition consensus documents made recommendations to address this issue. In cardiovascular randomised trials, we evaluated the impact of implementation of three key recommendations from these reports - troponin use to define MI; separate reporting of spontaneous and procedure-related MI; and infarct size reporting.  We searched ClinicalTrials.gov and MEDLINE databases for cardiovascular RCTs with more than 500 patients in which enrolment began between Sep 2000 and Jul 2012 and that listed MI in the primary endpoint.  We searched English-language publications with primary results or design papers. Of 3222 studies screened, 96 (3.0%) met our criteria.  We extracted enrolment start date, ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news