Effectiveness of casein phosphopeptide ‐amorphous calcium phosphate‐containing products in the prevention and treatment of white spot lesions in orthodontic patients: A systematic review

AbstractThe purpose of the present systematic review was to evaluate the effectiveness of casein phosphopeptide ‐amorphous calcium phosphate (CPP‐ACP)‐containing products in the prevention and treatment of active white spot lesions (WSL) in orthodontic patients. Searched the Scopus, PubMed, Web of Science, Cochrane, Virtual Health Language, ClinicalTrials, and Open Gray databases without limitations on the year or language of publication. We included controlled clinical trials with patients with fixed orthodontic appliances under the use of CPP‐ACP‐containing products compared to control, placebo, or other interventions in the prevention and treatment of WSL around orthodontic braces. Case rep orts, editorials, in vitro studies, annals of congress, and reviews were excluded. To assess the risk of bias, the revised version of the Cochrane tool for randomized trials (RoB 2.0) and Risk Of Bias In Non‐randomized Studies for non‐randomized trials were used. The biases were graded low, mode rate, and high according to the tools used. Of the 599 articles found, 11 met the inclusion criteria. Of these, nine were randomized, controlled clinical trials and two were non‐randomized. Two studies were considered to have moderate bias risk, and the most‐used CPP‐ACP presented form was a c ream for topical applications. Although CPP‐ACP‐containing products did not differ from other fluoride products, they were able to reduce WSL and neutralize the pH around the orthod...
Source: Journal of Investigative and Clinical Dentistry - Category: Dentistry Authors: Tags: REVIEW ARTICLE Source Type: research