Association of CYP2C19 and HSP70 genes polymorphism with aspirin-exacerbated respiratory disease in Kurdistan province.

Association of CYP2C19 and HSP70 genes polymorphism with aspirin-exacerbated respiratory disease in Kurdistan province. Recent Pat Endocr Metab Immune Drug Discov. 2019 May 26;: Authors: Kooti W, Abdi M, Malik YS, Nouri B, Jalili A, Rezaei MA, Rahmani MR, Kalmarzi RN Abstract BACKGROUND: CYP2C19 is a metabolizing enzyme and heat shock proteins (HSP) are induced in stress conditions, such as hypoxia and ischemia. Recently, polymorphism in CYP2C19 and HSP genes has been observed in aspirin-exacerbated respiratory disease (AERD). OBJECTIVE: We investigated the polymorphism of these two genes in AERD cases within the Kurdistan population. METHODS: Study involved 306 subjects, referred to the Be'sat hospital in Kurdistan Province, and were divided into three groups, (i) Aspirin induced asthma (AIA), (ii) aspirin tolerant asthma (ATA), and (iii) healthy subjects as control. The subjects as control and ATA\AIA groups were verified by the physician. The demographic data (age, sex, parental education, and residence) was collected for all the subjects. Spirometry was performed on subjects and blood samples were collected for serum immunoglobulin E and further molecular tests. Genotyping was done for CYP2C19 681G>A، CYP2C19 636G>A and HSPA1B1267A>G by using PCR-RFLP and for HSPA1B-179C>T by HRM. RESULTS: Demographic data were not significantly different between the three groups (p>0.05). Further, genotype...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research