Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma

This study highlights significant differences in the EC intergrades immune status especially the tumor-infiltrating c ell types and their activation status as well as in the molecular factors produced by the environment. The immune microenvironment of grade 1 ECs hints at a robust tumoricidal milieu while that of higher grades is more evocative of a tolerogenic milieu. This genes-based immunological monitoring of t umors that easily highlights significant intergrade differences relating to the density, composition and functional state of the leukocyte infiltrate, could give solid arguments for choosing the best therapeutic options, especially those targeting immune checkpoints. Moreover it could enable an easy adaptation of individual treatment approaches for each patient.
Source: Cancer Microenvironment - Category: Cancer & Oncology Source Type: research