Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis

Source: BMJ Area: News According to the results of a systematic review and meta-analysis, there is no evidence to support the use of vitamin and antioxidant supplements for the primary or secondary prevention of cardiovascular diseases (CVD).   The authors note that although several previous meta-analyses have evaluated the effect of vitamins and antioxidant supplements on CVD, they all involved individual vitamins or antioxidants, and none performed subgroup analyses by factors such as methodological quality or funding source. They sought to address these limitations in the current study. They identified a total of 50 RCTs (n=294,478) suitable for inclusion - 30 were primary prevention (varying patient characteristics) and 20 were secondary prevention - and they spanned 23 years (1989-2012).  The interventions and the dose regimens used varied.      The main results reported were as follows:   . In the fixed effect meta-analysis of all 50 trials, ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news