Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

ConclusionsThe classifier properties further highlight the contribution of the quantity of peptides reaching the ER and the mutation type to CD8  + T cell responses. These classifiers were then validated on neo-antigens obtained from other datasets, confirming the validity of our prediction.Algorithm Availability:http://peptibase.cs.biu.ac.il/Tcell_predictor/ or by request from the authors as a standalone code.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research