Experimental models in traumatic brain injury: From animal models to in vitro assays

Publication date: Available online 18 May 2019Source: Medicina Intensiva (English Edition)Author(s): L. Sempere, A. Rodríguez-Rodríguez, L. Boyero, J.J. Egea-GuerreroAbstractTraumatic brain Injury (TBI) is a major public healthcare concern, affecting people of all ages. Despite advances in the diagnosis, monitoring and clinical management of TBI, many unresolved questions remain regarding its physiopathology. In an attempt to understand the pathological features of TBI and to evaluate single potential therapeutic strategies, various animal models have been developed to simulate the mechanisms of action and the clinical manifestations of TBI patients. In turn, each model represents a specific type of trauma and evaluates a specific physiopathological aspect of the cascade triggered as a result of TBI.This review describes the main experimental models currently available referred to TBI and their possible application to the clinical setting.ResumenEl traumatismo craneoencefálico (TCE) es una de las patologías más importantes en la actualidad, ya que afecta a un alto porcentaje de individuos de todas las edades. A pesar de los avances en el campo del diagnóstico, la monitorización y el tratamiento del TCE, quedan importantes cuestiones sin resolver alrededor de la fisiopatología de este tipo de traumatismo. Con el fin de profundizar en dicho conocimiento y poder evaluar y aplicar un posible tratamiento que resulte eficaz para estos pacientes, se han desarrollado diferent...
Source: Medicina Intensiva - Category: Intensive Care Source Type: research