Phenotypes of allergic diseases in children and their application in clinical situations.

Phenotypes of allergic diseases in children and their application in clinical situations. Korean J Pediatr. 2019 Apr 23;: Authors: Lee E, Hong SJ Abstract Allergic disease, including allergic rhinitis, asthma, and atopic dermatitis, are huge heterogeneous diseases, encompassing diverse phenotypes with different pathogenesis. Phenotype studies on allergic diseases are important in that they can facilitate the identification of risk factors and the underlying pathophysiologies, resulting in the application of more effective treatment, selection of better response to the treatment, and prediction of prognosis for each phenotype. In the early phase of phenotype studies in allergic diseases, artificial classifications were usually performed on the basis of clinical features, such as triggering factors or presence of atopy, which can result in the biased classification of phenotypes and be limited in the characterization of heterogeneous allergic diseases. Subsequent phenotype studies have suggested more diverse phenotypes in each allergic disease, using relatively unbiased statistical methods, such as cluster analysis or latent class analysis. The classifications of phenotypes in allergic diseases may overlap or be unstable over time due to their complex interactions with genetic and encountered environmental factors during the illness, which may affect the disease course and pathophysiologies. In this review, diverse phenotype classifica...
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research