Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells

We demonstrated three novel forms of dynamic behaviour of junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) in migrating cancer cells: saltatory formation, long distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5µm of polymerised actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junctions accompanied the tail withdrawal.

Source: BJ Cell - January 16, 2013 Category: Biochemistry Authors: H Dingsdale, E Okeke, M Awais, L P Haynes, D N Criddle, R Sutton, A V Tepikin Tags: BJ Cell Source Type: research