Comparative analysis of the utility of GATA-binding protein 3 opposed to gross cystic disease fluid protein-15 in the diagnosis of metastatic breast carcinomas and diverse molecular subtypes

Background Estrogen receptor, gross cystic disease fluid protein-15 (GCDFP-15), and mammaglobin are molecular markers generally used to delineate breast origin. However, these breast-specific markers are frequently lost in triple-negative tumors and some metastatic breast carcinomas. Lately, GATA-binding protein 3 (GATA-3) has emerged as a putative marker in the diagnosis of mammary carcinoma, a relatively specific immunomarker for the breast. Aim The aim of this study was to compare the diagnostic performance of GATA-3 and GCDFP-15 in distinguishing metastatic tumor of breast primary and its diverse molecular subtypes. Patients and methods GATA-3 and GCDFP-15 immunoexpression was analyzed in 105 cases, which included primary invasive breast carcinomas (n=60), metastatic breast carcinomas (n=25), and metastatic carcinomas other than the breast (n=20). Hormonal receptor studies categorized primary carcinomas into their molecular subtypes. Results In primary and metastatic breast carcinomas, GATA-3 expression was significantly higher than GCDFP-15 (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research