Snail-1, ALDH1, and claudin-1 tissue protein expression in patients with colorectal cancer: clinicopathological and prognostic implications

In this study, we aimed to determine whether EMT markers, the expression of stem cell markers, and levels of the tight junction proteins are associated with the clinical and pathological features and clinical prognosis of patients with CRC by evaluating tissue protein expression of Snail-1, ALDH1, and claudin-1. Patients and methods Expressions of Snail-1, ALDH1, and claudin-1 were evaluated in sections from 50 paraffin blocks that were retrieved from 50 patients having CRC. We have followed up the patients for 3 years. We correlated expression of markers with clinical, pathological, and follow-up parameters. Results Both Snail-1 and ALDH1 are overexpressed in CRC cells mainly in tumors located in the ascending colon (P=0.012 and 0.003, respectively), and their expression was directly correlated with high grade (P=0.002 and 0.005, respectively), larger tumor size (P=0.031 and 0.007, respectively), presence of lymph node metastasis (P=0.003 and 0.004, respectively), distant metastases (P=0.004 and 0.021, respectively), and advanced American Joint committee of Cancer stage (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research