Photocontrol of Peptide Secondary Structure through Non-Azobenzene Photoswitches

Publication date: Available online 11 May 2019Source: Journal of Photochemistry and Photobiology C: Photochemistry ReviewsAuthor(s): Victoria Peddie, Andrew D. AbellAbstractThe rapidly expanding field of photoswitchable biomolecules is a major frontier in scientific research and provides unparalleled opportunities for studying biological pathways and disease progression. In particular, the development of photochromic peptides has delivered both scientific tools and candidates for photopharmaceuticals. The action and function of the peptide can be remotely altered using light, allowing detection of its biological role in complex biological settings, while also enabling folding studies that provide greater understanding of protein structure dynamics. In this review we provide a key, comprehensive overview of the different types of photoswitches that have been used to control peptide structure, excluding the already extensively reviewed azobenzene. This will help address the question as to which synthetic photoswitch to use in a given study.Graphical abstract

Source: Journal of Photochemistry and Photobiology C: Photochemistry Reviews - May 13, 2019 Category: Chemistry Source Type: research