Spontaneous esophageal perforation in a patient with mixed connective tissue disease.

Spontaneous esophageal perforation in a patient with mixed connective tissue disease. Open Rheumatol J. 2011;5:138-43 Authors: Lyman D Abstract Spontaneous esophageal perforation is a rare and life-threatening disorder. Failure to diagnosis within the first 24-48 hours of presentation portends a poor prognosis. A patient with mixed connective tissue disease (MCTD) on low-dose prednisone and methotrexate presented moribund with chest and shoulder pain, a left hydropneumothorax, progressive respiratory failure and shock. Initial management focussed on presumed community acquired pneumonia (CAP) in a patient on immunosuppressants. Bilateral yeast empyemas were treated and attributed to immunosuppression. On day 26, the patient developed mediastinitis, and the diagnosis of esophageal perforation was first considered. A review of the literature suggests that the diagnosis and management of spontaneous esophageal perforation could have been more timely and the outcome less catastrophic. PMID: 22279514 [PubMed]
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research