Pentosidine, an advanced glycation end-product, may reflect clinical and morphological features of hand osteoarthritis.

Pentosidine, an advanced glycation end-product, may reflect clinical and morphological features of hand osteoarthritis. Open Rheumatol J. 2012;6:64-9 Authors: Braun M, Hulejová H, Gatterová J, Filková M, Pavelková A, Sléglová O, Kaspříková N, Vencovský J, Pavelka K, Senolt L Abstract The study investigates pentosidine levels, an advanced glycation end-product, in patients with erosive and non-erosive hand osteoarthritis (HOA) and determine its potential association with clinical findings and imaging-defined joint damage.Pentosidine was measured by HPLC in serum and urine of 53 females with HOA (31 erosive and 22 non-erosive HOA) and normalised to the total serum protein or urinary creatinine, respectively. Pain, joint stiffness and disability were assessed by the Australian/Canadian OA hand index (AUSCAN). The hand radiographs scored according to the Kallman grading scale were assessed to determine a baseline value and reassessed after two years.The levels of urine pentosidine, but not of serum pentosidine, were higher in patients with erosive HOA than in non-erosive HOA (p=0.039). Urinary pentosidine correlated with CRP (r=0.302, p=0.031), ESR (r=0.288, p=0.041) and AUSCAN (r=0.408, p=0.003). Serum pentosidine, but not in urine, significantly correlated with the Kallman radiographic score in erosive HOA at the baseline (r=0.409, p=0.022) and after 2 years (r=0.385, p=0.032). However, when corrected for age and disease dura...
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research