JAK Kinases in Health and Disease: An Update.

JAK Kinases in Health and Disease: An Update. Open Rheumatol J. 2012;6:232-44 Authors: Laurence A, Pesu M, Silvennoinen O, O'Shea J Abstract Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors. PMID: 23028408 [PubMed]
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research