Altered Biodistribution of Radiopharmaceuticals Used in Bone Scintigraphy

Bone scintigraphy has remained a mainstay of clinical nuclear medicine for more than 4 decades. Extensive medical literature has developed surrounding the etiology and significance of alterations in distribution of bone radiopharmaceuticals. Altered biodistribution may be of a global nature, reflecting altered partition of radiopharmaceutical between bone and soft tissues, or more focal, reflecting regional abnormalities, including those related to bone or soft tissues. A third category of alterations in the distribution of bone radiopharmaceuticals is those due to errors and blunders, colloquially termed “artifactual” in the medical imaging literature.

Source: Seminars in Nuclear Medicine - December 2, 2014 Category: Radiology Authors: Lionel S. Zuckier, Patrick Martineau Source Type: research