Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

Publication date: Available online 6 May 2019Source: Trends in Pharmacological SciencesAuthor(s): Carlotta GranchiATP-citrate lyase (ACLY) is an enzyme that links glycolysis to lipid metabolism. To date only partial X-ray structures of ACLY have been solved, thus limiting the design of novel inhibitors. Wei and colleagues (published online in Nature April 3, 2019) now report the full X-ray structure of human ACLY in complex with NDI-091143, revealing an appealing allosteric inhibition mechanism for this compound.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research