Bioinformatic applications in psoriasis: genetics, transcriptomics, and microbiomics.

Bioinformatic applications in psoriasis: genetics, transcriptomics, and microbiomics. Semin Cutan Med Surg. 2019 Mar 01;38(1):E3-E11 Authors: Parad JE, Liao W Abstract Bioinformatics uses computationally intensive approaches to make sense of complex biological data sets. Here we review the role of bioinformatics in 3 areas of biology: genetics, transcriptomics, and microbiomics. Examples of bioinformatics in each area are given with respect to psoriasis and psoriatic arthritis, related inflammatory disorders at the forefront of bioinformatic research in dermatology. While bioinformatic technologies and analyses have traditionally been developed and deployed in siloes, the field of integrative omics is on the horizon. Powered by the advent of machine learning, bioinformatic integration of large data sets has the potential to dramatically revolutionize our knowledge of pathogenetic mechanisms and therapeutic targets. PMID: 31051017 [PubMed - in process]
Source: Seminars in Cutaneous Medicine and Surgery - Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research