Neurons regulate synaptic strength through homeostatic scaling of active zones

How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.

Source: Journal of Cell Biology - May 5, 2019 Category: Cytology Authors: Cunningham, K. L., Littleton, J. T. Tags: Trafficking, Neuroscience Spotlight Source Type: research