A CRACker of an adaptor connects dynein-mediated transport to calcium signaling

Many different adaptor proteins activate the processivity of dynein–dynactin complexes and determine the specific cargo for retrograde transport by binding cargo receptors such as Rab GTP-binding (G) proteins. In this issue, Wang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806097) identify two GTPases that can function directly as dynein adaptors during endocytosis and are regulated by calcium.

Source: Journal of Cell Biology - May 5, 2019 Category: Cytology Authors: Sharma, M., Dwivedi, D. Tags: Spotlight Source Type: research