Active RNA polymerase II curbs chromatin movement

Chromosomes are not very mobile during interphase. In this issue, Nagashima et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201811090) propose that the overall stabilization of genome structure is achieved by loose connections between DNA regions brought about by transcriptionally active RNA polymerases.

Source: Journal of Cell Biology - May 5, 2019 Category: Cytology Authors: Hochberg-Laufer, H., Shav-Tal, Y. Tags: Spotlight Source Type: research