Impact of the glyphosate-based commercial herbicide, its components and its metabolite AMPA on non-target aquatic organisms

Publication date: Available online 4 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Laís de Brito Rodrigues, Gessyca Gonçalves Costa, Emanoela Lundgren Thá, Lucas Rafael da Silva, Rhaul de Oliveira, Daniela Morais Leme, Marta Margarete Cestari, Cesar Koppe Grisolia, Marize Campos Valadares, Gisele Augusto Rodrigues de OliveiraAbstractGlyphosate (GLY) is the active ingredient of several herbicide formulations widely used to control weeds in agricultural and non-agricultural areas. Due to the intensive use of GLY-based herbicides and their direct application on soils, some of their components, including the active ingredient, may reach the aquatic environment through direct run-off and leaching. The present study assessed the acute toxicity and genotoxicity of the GLY-based formulation Atanor 48 (ATN) and its major constituents GLY, surfactant polyethoxylated tallow amine (POEA), as well as the main metabolite of GLY aminomethylphosphonic acid (AMPA) on non-target aquatic organisms. The toxic effects of these chemicals were evaluated in the fish embryo acute toxicity test with zebrafish (Danio rerio), while genotoxic effects were investigated in the comet assays with cells from zebrafish larvae and rainbow trout gonad-2 (RTG-2). GLY and AMPA caused no acute toxic effect, while ATN and POEA induced significant lethal effects in zebrafish (LC50-96 h 76.50 mg/L and 5.49 mg/L, respectively). All compounds were genotoxic in come...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research