Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia.

Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia. Stroke Res Treat. 2013;2013:425281 Authors: Tso MK, Macdonald RL Abstract Subarachnoid hemorrhage and transient global cerebral ischemia result in similar pathophysiological changes in the cerebral microcirculation. These changes include microvascular constriction, increased leukocyte-endothelial interactions, blood brain barrier disruption, and microthrombus formation. This paper will look at various animal and preclinical studies that investigate these various microvascular changes, perhaps providing insight in how these microvessels can be a therapeutic target in both subarachnoid hemorrhage and transient global cerebral ischemia. PMID: 23589781 [PubMed]
Source: Stroke Research and Treatment - Category: Neurology Tags: Stroke Res Treat Source Type: research