Urate and risk of Alzheimer's disease and vascular dementia: A population-based study

We examined whether sU (determined in 1968–1969 and 1992–1994) is associated with risk of late-life dementia.ResultsDuring 44 years of follow-up, a higher sU (per standard deviation of 76.5 μmol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72–0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66–0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47–0.94).DiscussionOur findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research