Heat-shock protein ClpL/HSP100 increases penicillin tolerance in Streptococcus pneumoniae.

Heat-shock protein ClpL/HSP100 increases penicillin tolerance in Streptococcus pneumoniae. Adv Otorhinolaryngol. 2011;72:126-8 Authors: Tran TD, Kwon HY, Kim EH, Kim KW, Briles DE, Pyo S, Rhee DK Abstract Penicillin resistance and tolerance has been an increasing threat to the treatment of pneumococcal pneumoniae. However, no penicillin tolerance-related genes have been claimed. Here we show that a major heat shock protein ClpL/HSP100 could modulate the expression of a cell wall synthesis enzyme PBP2x, and subsequently increase cell wall thickness and penicillin tolerance in Streptococus pneumoniae. PMID: 21865709 [PubMed - indexed for MEDLINE]
Source: Advances in Oto-Rhino-Laryngology - Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research