In yeast cells arrested at the early S-phase by hydroxyurea, rRNA gene promoters and chromatin are poised for transcription while rRNA synthesis is compromised

This study indicates a hitherto unexplored cellular response to HU, namely altered rRNA synthesis, which could participate to hamper cell division.

Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - April 28, 2019 Category: Cytology Source Type: research