Chronic Occupational Noise Exposure: Effects on DNA Damage, Blood Pressure, and Serum Biochemistry

Publication date: Available online 26 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Majid Bagheri Hosseinabadi, Narges Khanjani, Thomas Münzel, Andreas Daiber, Mohammad YaghmorlooAbstractNoise levels experienced by industrial workers may cause both auditory and non-auditory harmful effects. We have studied the effect of chronic industrial noise exposure on DNA damage, blood pressure, and serum biochemistry in factory workers. Male workers (109 individuals) in three parts of a food factory in Shahroud, Iran were enrolled as the exposed group and male office workers (123 individuals) were the unexposed control group. Noise exposure was measured (dosimetry) and the comet assay was used to evaluate DNA damage in peripheral blood mononuclear cells. Glutathione peroxidase (GPx) and ceruloplasmin (Cp) levels were measured in serum samples. GPx levels, systolic and diastolic blood pressure, and DNA damage were significantly higher in the exposed group than in the control group. However, ceruloplasmin levels were not significantly different. Based on multivariate linear regression analysis, noise exposure was the most important predictor of GPx levels, systolic and diastolic blood pressure, and DNA damage.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research