Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth

This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain® gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino–pulpal complex regeneration.

Source: Journal of Tissue Engineering - February 2, 2014 Category: Biotechnology Authors: Darwish, S. S., Abd El Meguid, S. H., Wahba, N. A., Mohamed, A. A.-R., Chrzanowski, W., Abou Neel, E. A. Tags: Article Source Type: research