If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

Source: East Anglia Medicines Information Service Area: Evidence > Medicines Q & A If the hyponatraemia is mild (125-134mmol/litre serum sodium) and there is no other cause for the hyponatraemia, discontinue the antidepressant and monitor serum sodium levels daily until they are within normal range or if asymptomatic, consider fluid restriction. If the patient has serum sodium below 125mmol/litre, discontinue the antidepressant immediately and treat medically for hyponatraemia. After serum sodium levels have normalised, choose another appropriate antidepressant. If the patient developed hyponatraemia whilst on an SSRI or venlafaxine, consider changing to a TCAD or an MAOI. The increased risk of overdose, adverse effects, and drug interactions of these antidepressants must be considered before prescribing. Monitor serum sodium levels weekly initially. Tryptophan has not been linked to hyponatraemia; however, it is only licensed for initiation by a hospital specialist in treatment-resistant depression after trials of standard antidepressant drug ...
Source: NeLM - Mental Health - Category: Psychiatry Source Type: news