Polycystic kidney disease - where gene dosage counts.

Polycystic kidney disease - where gene dosage counts. F1000Prime Rep. 2014;6:24 Authors: Eccles MR, Stayner CA Abstract Gene dosage effects have emerged as playing a central role in the pathogenesis of polycystic kidney disease. Yet, how gene dosage can ultimately have an impact on the formation of kidney cysts remains unknown. In this commentary we review the evidence for the role of gene dosage effects versus the "2-hit" mutation model in polycystic kidney disease (PKD), and also discuss how gene networks may potentially make intertwined contributions to PKD. PMID: 24765529 [PubMed]
Source: F1000 Medicine Reports - Category: Biomedical Science Tags: F1000Prime Rep Source Type: research