Altered gene expression profile after exposure to transforming growth factor β1 in the 253J human bladder cancer cell line.

CONCLUSIONS: A list of genes showing significantly altered expression profiles after TGF-β1 treatment was made according to five highly cohesive clusters. The data suggest that the growth inhibitory effect of TGF-β1 in bladder cancer may occur through the Smad-dependent pathway, possibly via activation of the extracellular signal-related kinase 1 and Jun amino-terminal kinases Mitogen-activated protein kinase pathway. PMID: 25132950 [PubMed - in process]
Source: Korean Journal of Urology - Category: Urology & Nephrology Tags: Korean J Urol Source Type: research