Practice for Preterm Patent Ductus Arteriosus; Focusing on the Hemodynamic Significance and the Impact on the Neonatal Outcomes.

Practice for Preterm Patent Ductus Arteriosus; Focusing on the Hemodynamic Significance and the Impact on the Neonatal Outcomes. Korean J Pediatr. 2019 Apr 08;: Authors: Lee JA Abstract Hemodynamically significant preterm patent ductus arteriosus (PDA) has been known to affect mortality, morbidities such as necrotizing enterocolitis, intra-ventricular hemorrhage, bronchopulmonary dysplasia, and adverse long-term neurodevelopmental outcomes in preterm infants, especially in very low birth weight infants. However, recent researches indicate that there is no consensus about the causal relationship between the PDA and neonatal outcomes, the benefit or lack of treatment, the factors guiding the need to treat, and about the optimal treatment strategies. Such uncertainty made the practice about preterm PDA vary between units, regions, and nations widely. Nowadays, there are tendencies of the paradigm shift to more conservative treatment about preterm PDA and the suggestions about selective management of preterm PDA considering risk factors and hemodynamic significance are increasing. Neonatologist-performed echocardiography and advances in modalities to assess hemodynamic significance such as biologic markers and near-infrared spectroscopy also help to improve the efficacy of selective treatment of preterm PDA. PMID: 30999726 [PubMed - as supplied by publisher]
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research