The geometric framework: An approach for studying the impact of nutrition on healthy aging

Publication date: Available online 16 April 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Samantha M. Solon-Biet, Devin Wahl, David Raubenheimer, Victoria C. Cogger, David G. Le Couteur, Stephen J. SimpsonThe most robust interventions that impact on the biological processes of aging and age-related diseases are nutritional (caloric restriction, protein restriction, intermittent fasting) or those pharmacological and genetic interventions that act on nutrient sensing pathways. The best established nutritional intervention is caloric restriction, but this is not feasible in most humans; therefore, other nutritional interventions that influence aging but do not involve protracted periods of fasting have been studied. The Geometric Framework provides a powerful research tool for disentangling the effects of various nutrients and calorie intake, in both restricted and ad libitum-fed diets, on phenotypic outcomes such as aging and lifespan. This approach can also be applied to understanding the complex network of nutrient sensing pathways, potentially identifying new targets for the development of drugs that influence healthy aging.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research