Access to NH-aziridine-2-carboxamides through Davidsen acylimidodicarbonate activation

Publication date: Available online 11 April 2019Source: Comptes Rendus ChimieAuthor(s): Jekaterīna Ivanova, Boriss Štrumfs, Raivis ŽalubovskisAbstractAcylimidodicarbonates obtained from aziridine-2-carboxamides through Davidsen bis-Boc activation react with amine nucleophiles under mild conditions to form tertiary aziridine-2-carboxylic acid amides. NH aziridine-2-carboxylic acid amides were obtained by hydrogenolythic deprotection of N-Cbz derivatives.

Source: Comptes Rendus Chimie - April 13, 2019 Category: Chemistry Source Type: research