Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction

Publication date: Available online 6 April 2019Source: Advances in Biological RegulationAuthor(s): Rhîan Gaenor Jacobsen, Fatemeh Mazloumi Gavgani, Amanda J. Edson, Marianne Goris, Altanchimeg Altankhuyag, Aurélia E. LewisAbstractBiomolecular interactions between proteins and polyphosphoinositides are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. Polyphosphoinositides (PPIns) are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combinations. PPIns signal by recruiting proteins via canonical domains or short polybasic motifs. Although their actions are predominantly documented on cytoplasmic membranes, six of the seven PPIns are present within the nucleus together with the PPIn kinases, phosphatases and phospholipases that regulate their turnover. Importantly, the contribution of nuclear PPIns in the regulation of nuclear processes has led to an increased recognition of their importance compared to their more accepted cytoplasmic roles. This review summarises our knowledge on the identification and functional characterisation of nuclear PPIn-effector proteins as well as their mode of interactions, which tend to favour polybasic motifs.

Source: Advances in Biological Regulation - April 7, 2019 Category: Biology Source Type: research