Nef, the shuttling molecular adaptor of HIV, influences the cytokine network

Complex retroviruses belonging to the Lentivirus genus produce a number of viral proteins in addition to the classical structural and enzymatic factors codified by all retroviruses through the gag (group-specific antigen), pol (polymerase) and env (envelope) genes. In particular Human Immunodeficiency Virus (HIV) encodes two regulatory proteins essential for viral replication (i.e., the transcriptional transactivator Tat and the regulator of virion gene expression Rev) and four so-called “accessory proteins”, i.e.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research