Dual roles of EZH2 in acute myeloid leukemia

In this issue of JEM, Basheer et al. (https://doi.org/10.1084/jem.20181276) describe opposing roles of the epigenetic regulator Ezh2 during initiation and maintenance of acute myeloid leukemia (AML). Ezh2 was found to have tumor suppressive and oncogenic functions in different phases of the same malignancy.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Leukemia & Lymphoma Insights Source Type: research