Iron overload and liver cancer

In this issue of JEM, Muto et al. (https://doi.org/10.1084/jem.20180900) generate a novel mouse model of liver cancer induced by iron overload by deleting the iron-sensing ubiquitin ligase FBXL5 specifically in hepatocytes and exposure to a chemical carcinogen.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Solid Tumors, Tumor Immunology Insights Source Type: research