Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

http://jcb.rupress.org/cgi/content/short/218/4/1092?rss=1

Source: Journal of Cell Biology - March 31, 2019 Category: Cytology Authors: Nair, P. R., Wirtz, D. Tags: Cytoskeleton, Migration, Motility, Biophysics Spotlight Source Type: research

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