miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor.

In this study, we demonstrate the potential role of miR-27 in the regulation of mitochondrial dynamics. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. Expression of miR-27 results in the elongation of mitochondria as well as an increased mitochondrial membrane potential and mitochondrial ATP level. Our results suggest that miR-27 is a novel regulator affecting morphological mitochondrial changes by targeting MFF.
PMID: 25431021 [PubMed - in process]

Source: exp Mol Med - November 29, 2014 Category: Molecular Biology Authors: Tak H, Kim J, Jayabalan AK, Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK Tags: Exp Mol Med Source Type: research