A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury

Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is now a well-recognized and potentially severe complication of HSCT that carries a high risk of death. In those who survive, TA-TMA may be associated with long-term morbidity and chronic organ injury. Recently, there have been new insights into the incidence, pathophysiology, and management of TA-TMA. Specifically, TA-TMA can manifest as a multi-system disease occurring after various triggers of small vessel endothelial injury, leading to subsequent tissue damage in different organs.

Source: Blood Reviews - November 28, 2014 Category: Hematology Authors: Sonata Jodele, Benjamin L. Laskin, Christopher E. Dandoy, Kasiani C. Myers, Javier El-Bietar, Stella M. Davies, Jens Goebel, Bradley P. Dixon Tags: REVIEW Source Type: research