Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

In conclusion, imipenem and cilastatin are the substrates of OAT1 and OAT3. OAT1 and OAT3 mediate the DDI between imipenem and cilastatin. Meanwhile, cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement.Graphical abstract
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research