Betaine supplementation improved L-threonine fermentation of Escherichia coli THRD by upregulating zwf (glucose-6-phosphate dehydrogenase) expression

ConclusionsWe reveal a novel mode of betaine facilitating the microbial production of useful compounds. Betaine supplementation upregulates the expression of zwf and increases the NADPH synthesis, which may be beneficial for the cell growth and thereby promote the production of L-threonine. This finding might be useful for producing NADPH-dependent amino acids and derivatives in E. coli THRD or other E. coli strains.
Source: Electronic Journal of Biotechnology - Category: Biotechnology Source Type: research