Clinical relevance of cagA and vacA and association with mucosal findings in Helicobacter pylori-infected individuals from Chennai, South India

In this study, an attempt was made to correlate endoscopic mucosal patterns with H. pylori infection and examine the pathogenic potential of the strains. Among the 147 dyspeptic individuals studied, 42.2% were H. pylori infected. Association of H. pylori with type 3 and 4 mucosal patterns (P = 0.001) and intestinal metaplasia (P = 0.012) was seen. vacA was associated with histological (P = 0.014) and endoscopy findings (P = 0.009). Association of mucosal patterns with H. pylori infection could be useful for clinicians to decide on the need for eradication therapy.

Source: Indian Journal of Medical Microbiology - March 17, 2019 Category: Microbiology Authors: Anand Vadivel C P. Girish Kumar K Muthukumaran G Ramkumar R Balamurali Rang Lal Meena S Venkatasubramanian T Rajkumar Solomon P Ganesh S Jeevan Kumar Source Type: research