Identification of a novel lineage of plasmids within phylogenetically diverse subclades of IncHI2-ST1 plasmids

Publication date: Available online 15 March 2019Source: PlasmidAuthor(s): Piklu Roy Chowdhury, Mathieu Fourment, Matthew Z. DeMaere, Leigh Monahan, John Merlino, Thomas Gottlieb, Aaron E. Darling, Steven P. DjordjevicAbstractIncHI2-ST1 plasmids play an important role in co-mobilizing genes conferring resistance to critically important antibiotics and heavy metals. Here we present the identification and analysis of IncHI2-ST1 plasmid pSPRC-Echo1, isolated from an Enterobacter hormaechei strain from a Sydney hospital, which predates other multi-drug resistant IncHI2-ST1 plasmids reported from Australia. Our time-resolved phylogeny analysis indicates pSPRC-Echo1 represents a new lineage of IncHI2-ST1 plasmids and show how their diversification relates to the era of antibiotics.
Source: Plasmid - Category: Biotechnology Source Type: research